Eudesmanolides from Chloranthus elatior
Tuesday, April 17, 2012

Chlorantholides A–F, eudesmane-type sesquiterpene lactones from Chloranthus elatior

Fei Wang*, Dong-Sheng Zhou, Guo-Zhu Wei, Fu-Cai Ren, Ji-Kai Liu*

Phytochemistry, 2012, 77: 312-317

   Six eudesmane-type sesquiterpene lactones, named chlorantholides A–F (16), were isolated from the ethanol extract of Chloranthus elatior (Chloranthaceae) together with 12 known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis, and their absolute configurations were studied by the CD exciton chirality method. The structure of a recently reported eudesmanolide from Chloranthus anhuiensis: 8β-hydroxy-1-oxoeudesma-3,7(11)-dien-12,8-olide, was also revised as 8β-hydroxy-2-oxoeudesma-3,7(11)-dien-12,8-olide (chlorantholide D).

   ► Six new eudesmane sesquiterpene lactones were isolated from Chloranthus elatior.

   ► The structure of an eudesmanolide was revised.

   ► The HMBC and ROESY correlations of hydroxy proton signals were applied for structure elucidation.

   ► The CD exciton chirality method was employed to determine absolute configuration.